It's funny I don't associate the two either and I caught some of the WC ep Bottlenecked after Chuck and Matt Bomer looked so different. He looks older. Aging well of course. ;)

He has said if they wanted him back on Chuck (and was available) he'd love to do more. Seeing as Bryce has "died" before and come back it's possible. Although thinking about it I'm not sure more they could do with Bryce.